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KMID : 0525720160210030181
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Journal of Chitin and Chitosan
2016 Volume.21 No. 3 p.181 ~ p.187
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Optimization of Soluble Rutin using Stevioside as a Natural Solubilizer
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Ko Jin-A
Nam Seung-Hee
Kim Young-Min
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Abstract
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Rutin, naturally phenolic bioactive compound, is a potent antioxidant and anti-inflammatory activity having poor water-solubility as a weak point. The rapid and simple soluble rutin successfully formed using microwave treatments with stevioside as a natural solubilizer. Soluble rutin was optimized by the Box-Behnken design according to the independent four factors such as stevioside concentration, rutin concentration, microwave power, and microwave treated time, respectively. Finally optimal soluble rutin was obtained around 100% yield at a conditions as 146 mg/mL of stevioside, 5.9 mg/mL of rutin, 50 W of microwave power, and 5 min of treated time. These study illustrated that the soluble rutin formed by stevioside and microwave treatment can be applicable for functional foods and cosmetic materials in pharmaceutical areas.
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KEYWORD
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Rutin, Solubilizer, Stevioside, Microwave, Responds surface methodology
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